![]() ![]() ![]() The extracts obtained from these plants are then evaluated using different in vitro assays as well as their effects on normal or tumor cells. In order to develop new drugs, different plants are being selected randomly or based on ethnobotanic and ethnopharmacologic knowledge. Approximately 60% of anticancer compounds and 75% of drugs for infectious disease come from natural products or their derivatives. Today, natural products still have a huge importance as a source of new drugs and leads. In the 1900s most medicines were obtained from the cooking, infusion, or maceration of roots, barks, leaves, or flowers. Natural products have long been investigated for their potential benefits. On the other hand, the extracts HEL and AEL were able to induce cell proliferation of normal fibroblast 3T3 cells. The flow cytometer results showed that these extracts induce cell death via the apoptosis pathway. The extracts MEL and HEL (250 µg/mL) were able to reduce the proliferation of HeLa cells up to 54.3% and 48.5%, respectively. The cell viability assay showed that the extracts were able to reduce viability from cancer cells such as HeLa and A549 cells. Furthermore, the DPPH assay values ranged from 62.8% to 88.3%. The Total Antioxidant Capacity (TCA) was expressed as equivalent ascorbic acid (EEA/g) and it was observed that the extracts showed values ranging from 59.31 to 97.76 EAA/g. Furthermore, the antioxidant activities were analyzed by in vitro assays and their effects on cell lineages by in vivo assays. Thin layer chromatography analysis revealed the presence of phenolic compounds, steroids, and/or terpenoídes. volubilis such as aqueous extract (AEL), methanol (MEL), ethanol (EEL), chloroform (CEL), and hexane (HEL). ![]() The aim of this work was to perform a chemical and biological analysis of different leaf extracts from P. Plukenetia volubilis Linneo, or Sacha inca, is an oleaginous plant from the Euphorbiaceae family. ![]()
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